A role for leptin in glomerulosclerosis?

passivity in waiting for godot and endgame: a psychoanalytic reading

this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...

A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.

Focal segmental glomerulosclerosis (FSGS) is a syndrome that involves kidney podocyte dysfunction and causes chronic kidney disease. Multiple factors including chemical toxicity, inflammation, and infection underlie FSGS; however, highly penetrant disease genes have been identified in a small fraction of patients with a family history of FSGS. Variants of apolipoprotein L1 (APOL1) have been lin...

A role for leptin in rheumatic diseases?

Leptin: a novel therapeutic role in lipodystrophy.

Lipodystrophic syndromes encompass a heterogeneous group of rare disorders characterized by partial or generalized loss of adipose tissue depots (1). They are commonly associated with dyslipidemia, hepatic steatosis, and severe insulin resistance (2). The fact that insulin resistance and the consequent progression to diabetes can result from either obesity or lipodystrophy reflects the crucial ...

A role for leptin in sustaining lymphopoiesis and myelopoiesis.

Although leptin is known for its regulation of food intake, it has many emerging roles in immune function. To better define the role of leptin in hematopoietic processes, a leptin-deficient obese mouse (ob/ob) and C57BL/6 lean wild-type controls were compared. Despite their large size and consumption of substantial amounts of nutrients, the ob/ob mice had only 60% as many nucleated cells in the...